Peer-reviewed research

Case Studies on Enabling Data-Rich, Parallelized Kinetic Analysis for Process Optimization with the ReactALL Platform

High-Throughput Algorithmic Optimization of In Vitro Transcription for SARS-CoV-2 mRNA Vaccine Production

Bayesian optimization of 11 IVT process parameters in 42 reactions across 5 rounds; 12% yield gain, 50% faster, up to 44% reagent reduction.

Multigram Electrochemical Hofmann Rearrangement Using a Spinning Three-Dimensional Anode

Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19

Electrochemical Recycling of Adenosine Triphosphate in Biocatalytic Reaction Cascades

Kilo-Scale Electrochemical Oxidation of a Thioether to a Sulfone: A Workflow for Scaling Up Electrosynthesis

A Kinase-cGAS Cascade to Synthesize a Therapeutic STING Activator

Diastereoselective one-pot enzymatic cascade to MK-1454, a clinical STING agonist.

Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19

Manufacturing Process Development for Belzutifan, Part 6: Ensuring Scalability for a Deoxyfluorination Reaction

Manufacturing Process Development for Belzutifan, Part 4: Nitrogen Flow Criticality for Transfer Hydrogenation Control

Characterization of Propionyl Phosphate Hydrolysis Kinetics by Data-Rich Experiments and In-Line Process Analytical Technology

Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 4: Formylation-Cyclization as a Flow-Batch Process Leads to Significant Improvements in Process Mass Intensity (PMI) and CO Generated versus the Batch-Batch Process

Stoichiometry Identification of Pharmaceutical Reactions Using the Constrained Dynamic Response Surface Methodology

Constrained Version of the Dynamic Response Surface Methodology for Modeling Pharmaceutical Reactions